Targeted breakage of paracentromeric heterochromatin induces chromosomal instability
نویسندگان
چکیده
منابع مشابه
Targeted breakage of paracentromeric heterochromatin induces chromosomal instability.
Current models suggest that genomic instability is crucial in the accumulation of the multiple alterations required for tumorigenesis. However, the nature of the initial damage responsible for the origin of genomic instability remains poorly understood. In this investigation we demonstrate that the nucleotide analog 2,6-diaminopurine (DAP) can be used to induce highly focused damage to the larg...
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ژورنال
عنوان ژورنال: Mutagenesis
سال: 1998
ISSN: 0267-8357,1464-3804
DOI: 10.1093/mutage/13.5.435